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Sildenafil is usually a strong and selective inhibitor of cGMP-distinct phosphodiesterase variety 5 (PDE5), which is chargeable for degradation of cGMP during the corpus cavernosum. The molecular framework of sildenafil is comparable to that of cGMP and acts as a aggressive binding agent of PDE5 from the corpus cavernosum, leading to a lot more cGMP and elevated penile response to sexual stimulation.
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